Archive for February, 2007

PC Users Fail to Defrag Their Computers - Survey

Wednesday, February 28th, 2007

More than 42% of PC users neglect to defragment their computers, according to a client-sponsored survey conducted by online opinion polling and market research service provider Vizu Corporation. This failure to conduct routine computer maintenance can adversely affect system performance for both home and enterprise users, slowing operations such as boot up, file retrieval, Web browsing, backups, and anti-virus and spyware scans as well as contributing to system crashes.

Nearly 16% of those who answered the poll said they had “no idea” what disk defragmentation is, while more than 26% said they never defrag their machines. The remaining respondents said they “frequently” defrag their systems using either a built-in manual defragmentation program designed to eliminate wasted space between file fragments (44.9%) or a standalone utility that automates the defrag process (13.1%).

Disk fragmentation is a byproduct of normal computer use. As files are created, modified and deleted, the computer stores different fragments of each file in non-contiguous sectors of the hard drive. This forces the PC to search through different parts of the disk to assemble a single file, slowing data recall in much the same way as storing different components of a toaster in different parts of a factory would slow an assembly line.

In recent years, the fragmentation problem has been exacerbated by the increasing size of applications, operating systems, and multimedia files such as songs, photos and movies. Also worsening fragmentation headaches is the exponential growth of storage, spurred in part by the availability of larger hard drives and in part by government regulations that require long-term archiving of business files.

Defragmentation reorganizes the file fragments on a hard disk into contiguous clusters that help speed response time. Tests have shown that activities such as word processing, email searches, Web surfing, and anti-virus and spyware scans can take almost 15 times longer on hard drives that have not been defragged than on those that have.

Experts recommend that end users defrag their computers on a regular basis to optimize performance, with frequency depending on the amount of usage, the type of work being performed, and how full the disk drive is. In enterprise environments, some analysts recommend daily defragmentation for critical systems and weekly defragmentation for non-critical systems.

Attention Acne Sufferers - 3 Easy Steps to Cleaner, Healthier Skin

Wednesday, February 28th, 2007

Step 1: Cleanse

The first and most important easy step is to gently cleanse the skin thoroughly of all excess oils, dirt and impurities at least twice daily, morning and evening, or as often as needed with a light, oil-free, natural cleanser. The key is to keep the skin as clean and free of excess oils, dirt and debris as possible without over-stripping the skin of its own natural pH balance.

Step 2: Exfoliate

The second easy step is to weekly exfoliate the skin of all old dead skin cells from the surface and extract the oils and impurities from deep within the pores, to reveal a fresh, new, healthier layer of skin. This is very important because you will see a noticeable difference and improvement in your skin’s overall tone and condition if you incorporate this easy step regularly into your weekly routine.

Step 3: Tone

The third easy step is to gently tone and freshen the skin daily after each time you cleanse and weekly after each time you exfoliate. It is very important that you use a toner because even the best of cleansers and exfoliators leave behind some remaining dirt, oils and impurities. With a gentle, oil-free, natural toner, all remaining dirt, oils and impurities are removed, leaving the skin looking and feeling clean, fresh, and clear.

Although there are many different brands and types of products in the market today, what works best for you will depend on your skin, and the level of severity of your oily, acne skin problem. You may be thinking, so how many different products do I need to have? Well, I’m here to tell you that you do not need to have a lot of different products and a separate one for each step nor be confused by a complicated acne skin care system. The latest and hottest trend in the marketplace today is the creation of natural acne skin care products that combine these basic steps for a much easier and simpler skin care system and routine such as 2 in 1 step formula products that cleanse, tone and exfoliate while maintaining the skin’s own natural moisture pH balance, all in one quick, and easy step.

It is my hope that you’ve found this information helpful and useful.

Written by Laura K. Halik, author specializing in providing natural solutions for people suffering with skin conditions such as acne, rosacea, psoriasis, or dry skin.

To receive a free 5 step guide containing easy to use professional makeup application tips and suggestions, go to: http://www.naturalconcealingmakeup.com/index.htm

To learn more about natural concealing cover makeup system and the care and coverage of skin conditions or scars, go to: http://www.naturalconcealingmakeup.com

Key Wind Mantel Clocks or Quartz Battery Mantel Clocks - What is the Best Choice?

Wednesday, February 28th, 2007

So many choices so little time. The mantel clock shopper today has hundreds of clocks to choose from. Large mantle clocks and small mantle clocks, key wound or quartz battery operated. The consumer must also wade through many different manufacturers like Howard Miller, Seth Thomas and Bulova. Each brand has a very nice selection of well-made clocks.

The biggest decision for a clock shopper comes next. Do you want a mechanical chiming clock in the tradition of the antique mantel variety or do you want to go with the simplicity of a battery-operated style. Both can be a good choice but each has their drawbacks. Here is a brief comparison of the two.

Battery operated quartz mantel designs come in many different styles from the contemporary to antique. These styles are much lighter in weight than their key wound cousins. The interior of the clock cabinet is almost empty. The battery-operated movement is very small and doesn’t even fill the case. These designs look exactly like a key-wound version and are very handsome on the fireplace mantel. Most people I have spoken to are very happy with the inexpensive price tag and their good looks. One downside about the battery operated mantle clocks is that they do have a different sound to the chime. These mantle styles operated by batteries produce sound from a small speaker mounted inside the clock. Most models sound great almost as good as the key wound styles. Let us not forget the best thing about battery-operated clocks. They never require winding.

Key wind mantle clocks are much more like the antique versions your parents had. These models are much heavier in weight and have hundreds of moving parts. The chiming clock mechanism usually creates a beautiful sound reminiscent of the antique clocks of the past. Most of these clocks actually have a strike and chime mechanism that produces the beautiful ringing sound. These styles usually are much more expensive than the quartz versions. These clocks do require winding at regular intervals to keep the clock running.

In my opinion nothing looks better on a fireplace mantel than a large mantle clock. These beautiful accents can be purchased in various wood colors like oak and mahogany to match your décor. Pay close attention to special features like nighttime shutoff. This feature is great for people that can’t sleep in the house with a chiming clock.

The best selection of Mantel Clocks can be found here
Mantel Clocks. You can find many of the items that I write about at this store.

Eight Steps to Making Your Own Wine

Wednesday, February 28th, 2007

There are eight steps you need to follow when making your own wine. This article provides a brief overview of each of these steps to help get you acquainted to what it takes to create your personal vintage. Enjoy!

  1. Harvesting obviously, the first step to any wine is grapes. Therefore, the first thing that must occur is the harvesting of grapes. There are two methods of harvesting:

    • Machine. Machines use plastic or rubber rods to beat the grapes from the vine. However, this is not desirable if you are creating a high end wine due to leaves and undesirable grapes that can also be collected.

    • Hand. This is the preferred method for harvesting grapes. Experienced harvesters use their skills to collect the most desirable grapes.

  2. Destemming. In this step, the stems are removed from the grapes. Stems carry harsh tannins so this is usually done before the grapes are crushed so as not to influence the wine.

  3. Crushing. Here the skins of the grapes are broken to release the fruit. Each winemaker will have their own preferences concerning the amount of crushing that should occur. For example, if he or she is trying to create a fruity aroma they might decide to leave the berries nearly intact.

  4. Primary Fermentation. In this step, yeast cells in the wine feed on sugars and produce carbon dioxide and alcohol. Winemakers will often add extra yeast to insure a stable conversion instead of simply relying on the yeast found on the grapes.

  5. Pressing. Here more juice is extracted when the grapes are pressed even further. This juice is usually not as high quality as that from the crushing stage because the free run juice has less contact with the skins and stems that have more tannins. Nonetheless, winemakers will use pressing to increase their grape yield. Usually, this pressed juice gets used in lower end wines.

  6. Secondary Fermentation. Aging and secondary fermentation happen at the same time. The yeast continues to ferment slowly. The goals of the winemaker will determine the length of time this fermentation will be allowed to continue. A fine wine might stay in oak barrels for quite some time while a cheaper variety could spend only a few months in stainless steel drums.

  7. Blending. In this step, winemakers might blend different batches of wine together in order to create a desired product. For example, if they feel that there is a deficiency in a particular vintage they might blend another wine with it to improve the batch. This might happen also if a winemaker is trying to change the tannin levels.

  8. Bottling. This is the final step. Here the wine is put into bottles. Sulfites are sometimes added to help end the fermentation process and preserve the wine. The bottle is then sealed with a cork.

While the process seems complicated, it makes logical sense. If you are sincere about creating a home vintage, then you might want to consider buying a wine making kit that can help simplify the process. Making wine at home can also help enhance your everyday wine drinking experience as you gain a more thorough knowledge of how it is created.

Cheers!

Melissa Kelly began her love of wine by drinking at the side of her brother whose extremely good taste in wine soon meant that she had to spend way more than she meant to for a bottle. Check out her website at http://www.wineinnapa.com. You will be able to find more about how to make wine information along with other wine related pages there.

How One Big Idea Can Reel In The Customers

Wednesday, February 28th, 2007

One big sales tip. When working with your prospects and customers focus on their needs and their customers’ challenges. That’s where the ideas are.

One big sales tip. Imagine you sell shower curtains and shower rods to hotel chains.

You call on hotel chains. You want to be different. Your big idea is to help hotels to differentiate their sleeping rooms is a bowed shower curtain rod.

In the shower - the space is the same, it just feels bigger and better. Why can’t a sales person think up big ideas like this?

One big sales tip. Everybody and his mother and grandmother has Pyrex measuring cups in their kitchen cabinets.

They lasted for years and demand was declining. One big idea - change the handle to make the measuring cups stackable and the rest is history. Sales take off!

Big ideas are everywhere! But you have to be looking for them. They’re not going to tap you on the shoulder and say “Here I am - ready or not!”

Big ideas are the result of one basic question and this is a huge sales tip for you to consider.

It’s an easy question and it seldom gets asked. It’s the incubator for all big ideas.

You’ll be amazed how customers will respond to you if you ask this question once a day.

Your customers will be delirious if you asked this question on every sales call.

Guess what - when you ask this question often you will attract the big ideas that you can share with your customers.

The question that leads to big ideas is “How can we do it better?” Keep asking this question and your plate will soon be filled with big ideas you can share with your customers.

Big ideas can win customers for a lifetime!

Use this link to sign-up for Jim’s F-R-E-E The Start Selling More Newsletter and to get your copy of his Special Report titled, “The 12 Dumbest Things Salespeople Do.” http://www.meisenheimer.com

Epoxy Floors - They Are All the Same, Right?

Wednesday, February 28th, 2007

When I though about putting an Epoxy floor on my well worn warehouse floor, I tackled the task with the optimism that my only job was to find out which company was the most reasonably priced and still gave a quality install. My education began there. All epoxy floor products are not created equal!

The first part of my education began with the discovery that there were several different types of epoxy floor applications - Epoxy paint, poured applications, self-leveling and troweled on. Wow!
So, lets put these in perspective before I get into the details. The quality and durability of these products ranks from Epoxy Paint on the lower end to Troweled-on at the upper end, with self-leveling being the middle of the road.

It is important to identify the needs of the job you are considering. Is it high traffic? Will there be heavy equipment rolling across it? How about chemical spills? Will smooth and slippery cause a problem? What do you expect its longevity to be? Is beauty an important factor? If your are doing, say, your garage floor at home to make it easily cleanable, the high traffic and beauty aren’t a factor, and longevity probably won’t justify a higher price. On the other hand, if you are doing a hotel hallway, hospital halls or a loading dock, most or all of these factors need to be considered.
Epoxy paint. For the home owner who uses his garage as a workshop, the cost and ease of application probably dictates your choice. If you have to redo it in five years, it still justifies the choice, and it is available in several colors. You can install it yourself or hire a local odd-jobs contractor. It would be a very bad choice for hotels, loading docks, kennels, and other high-traffic or heavy equipment areas. It is always slippery, it is a thin application compared to the other two, and there isn’t much beauty to it.

Self-leveling Epoxy floors. These products work great for small areas. Some can be done by a handy homeowner, others may need a skilled handyman. If you are doing a shower area, a small bathroom, steps or small kitchen areas and many other small jobs that don’t require choices such as smooth or non-slip, this may be perfect for you. Although they will outlast many other flooring materials and withstand a lot, they aren’t the choice for large areas that receive lots of abuse. Most self-leveling products offer a range of color choices.

Troweled-on Epoxy floors. When traffic wear matters, when you have to make a choice between slippery or non-skid, and still receive a beautiful floor, this is the first choice. Most troweled-on epoxy floor companies offer up to twenty-four design and color choices. It can be installed as either a smooth (hotel hallway) or non-slip (loading docks) finish. This type has the longest life expectancy of the three. It will stand up to heavy equipment, most spills, and rough treatment. It comes with one caveat; it is not a do-it-yourself application. In fact, you need to be sure that the installers are well trained in this particular product. Many a tradesman with years of concrete finishing have a hard time getting this product right. If this product is what you need, make sure that the company uses well-trained installers before you move ahead.

The next time you walk down a hospital hallway, or Hotel halls that have epoxy instead of carpet, pay attention to the seamless beauty of this floor – it’s probably a troweled-on epoxy floor.

For more information about epoxy floors and applications, visit www.commercialepoxyflooring.com

Lee has been writing ever since his 10th grade Lit teacher challenged him in poetry. Through out the years he has written everything from instruction manuals to poetry, including a dozen short stories and lots of poetry. One day he might just find time to finish the novel he has started.

The Need for Efficient Information Technology Extends to Defragmentation

Wednesday, February 28th, 2007

An interesting article in the St. Cloud (Minnesota) Times discusses the fact that businesses, in order to remain competitive, need information technology. But beyond that, companies must seriously evaluate business process management solutions to insure that the return-on-investment is higher than the cost. While automating customer resource management (CRM), databases, file, print, video, and many other functions can certainly assist speed of service delivery, it takes scrutiny and evaluation to make sure that speed actually occurs. Although one might not consider it, this is also very true of defragmentation solutions.

File fragmentation is certainly an enemy of computer performance, slowing down all the vital functions that IT is working so hard to deliver. When files are split into multiple pieces (fragments), the added I/O traffic for file retrieval is considerable, and system speed and, in severe cases, reliability suffers. Company employees, trying to service customers, are stuck between a rock and a hard place; slow service to the public means upset and perhaps even lost clients.

For many years, enterprises have employed defragmentation solutions so that files would be retrievable in as few fragments as possible, maximizing system performance. Originally, such solutions had to be operated manually. Then, the “standard” became scheduled defragmentation so that IT personnel could set it up to run at times when it would have the least impact on system resources and would accomplish the most benefit.

But the state of technology—and, unfortunately, the state of fragmentation—has only escalated. As disk capacities have approached terabyte levels and beyond, as file sizes have become gargantuan, and as the need for access has gone beyond constant and frantic, scheduled defragmentation is becoming outmoded. Due to unheard-of rates of fragmentation, the periodic scheduled defragmentation runs are no longer keeping up; fragmentation is being left behind after each run, and performance is continuing to suffer, especially on larger volumes.

Additionally, IT personnel, having to deal with technology’s ever-increasing complexity, are now having trouble finding the time to figure out and set up defragmentation schedules for the growing number of disks in their operations.

The solution would seem to be a new breed of defragmenter, one which ran consistently (instead of periodically) in the background to keep a handle on fragmentation levels. Because it is constantly and invisibly operating during computer uptime, it would also need to not have any impact on system resources. Such a solution would also mean that IT personnel would not need to put in the considerable time on analysis and scheduling, and would have their time to devote to their already-overwhelming workload.

Fortunately, such solutions are now appearing on the market, keeping in step with the many other technological advances which allow faster and better service.

Blu-Ray vs HD DVD - Round One

Wednesday, February 28th, 2007

Locked in a death match that harkens back to the Betamax vs. VHS wars of 25 years ago, two competing and incompatible formats designed to deliver HD (High-Definition) content from a HD DVD player to your HDTV, are in a stand off. Behind the scenes, the battle has been raging for years between the electronics manufacturers, movie studios and lawyers, but now the conflict will enter the arena that matters: you—the potential consumer. The first generation of DVD was born in 1997 and has had a spectacular run, but its days are numbered due to the oncoming HD DVD technology. In one corner, there is Blu-ray DVD, backed by Sony, Panasonic, Samsung, Apple and others. Supporting the HD DVD format is Toshiba, Microsoft, Sanyo and Intel. Some companies like LG are on both sides of the fence, which presumably puts them on the eventual winning and losing sides.
Since the players use different technologies, the HD DVD’s themselves are not interchangeable.

The Blu-ray players will require the Blu-ray discs; the HD DVD discs will not play the Blu-Ray discs, but will play discs made for them. Confused yet? Already the retail chains are getting an earful from consumers wondering why they have to suffer from the inability of companies to reach an agreement on a standard format. In addition, the news from Sony and Toshiba is that the delays continue in the introduction of the players. Think “sooner” or “later”, just like Vista, the new operating system from Microsoft (configured to play HD-DVD’s) that the release date keeps getting pushed further back. The movie studios (concerned about piracy) are planning to release most films in both formats, but consumers will have to be very careful to not buy the wrong DVD for their particular player.

There is also a split decision among the movie studios; supporting the HD DVD format contingent is: Universal, Studio Canal, Paramount, Warner, and the Weinstein Company. The Blu-ray side is: Paramount, Sony Pictures (MGM/Columbia Tri-Star), Disney (including Touchstone and Miramax), Fox, Lions Gate and Warner. The players will retail in the 500 to 1000 dollar range. There is concern in a few circles that some HD televisions might not be compatible with the copyright protection on the DVD units. And new costly cables to connect the units to the televisions could be another source of consumer dissatisfaction. If that wasn’t enough to add to the woes of Sony and Toshiba, it is estimated that only ten percent of US homes are properly configured to enjoy the superior audio available on the High-Definition DVD players, and only around 12 percent of the homes have the HDTV’s to appreciate the improved picture quality. Whether it’s hooray for Blu-ray, or the other way, we will not know for a few years, but it will definitely be an exciting chapter in the history of technology.

You will find only the best Dish Network deals in L. Dixon’s articles. Check back frequently for new submissions from Dixon about new technology and how you can find the best Dish Network Promotions for your home and family.

Where to Get Cheap Florida Condo Insurance

Wednesday, February 28th, 2007

Thanks to global warming, hurricanes, floods, fires, and other natural disasters are on the rise. And robbery and vandalism in Florida are at an all-time high. So if you own a condo and don’t have Florida condo insurance you risk losing everything you own. Here’s how to get cheap Florida condo insurance with an A-rated company.

Florida Condo Insurance

Most condominium association insurance policies only protect the condominium structure. It doesn’t protect your personal property or provide you with liability insurance.

Here’s what standard condo insurance covers:

Your Property

Condo insurance pays to replace your personal property when it’s stolen, or when it’s been damaged by fire, smoke, vandalism, natural disasters, or plumbing leaks. Condo insurance covers your property even if it’s stolen or damaged at a location other than your condo. Standard condo association insurance covers your interior walls, carpets, and ceiling.

To determine how much property coverage you need, take an inventory of your personal property and use the total value as your insurance amount

Your Assets

Condo insurance pays for another person’s bodily injury medical bills and property damage bills when you or your family are found to be at fault. It also pays for your legal fees.

You should have enough liability insurance to cover all your assets - savings accounts, CDs, stocks, bonds, etc. - in case a lawsuit is filed against you.

How to Get Cheap Florida Condo Insurance

In order to get the best price on Florida condo insurance you need to get quotes from a number of insurance companies. You can do this quickly and easily by visiting an insurance comparison website.

Insurance comparison websites work with large insurance companies who bid for you insurance business. At one of these sites you fill out a simple questionnaire with information about your condo and the type of insurance you want, then you receive quotes that you can compare.

The better insurance comparison sites have an articles section where you can get money-saving tips, and a chat feature where you can talk with an insurance professional so you can ask questions and get insurance advice (see link below.)

Before you visit one of these sites, check with your condominium association to find out what they cover, and have your current condo insurance policy handy to help answer any questions on the site’s questionnaire. As you fill in the questionnaire make sure to request the highest deductible you can afford, and all the discounts you’re eligible for, in order to get the cheapest quote.

Visit http://www.LowerRateQuotes.com/homeowners-insurance.html or click on the following link to get cheap Florida insurance quotes online from top-rated companies and see how much you can save. You can get more insurance tips in their Articles section.

The author, Brian Stevens, is a former insurance agent and financial consultant who has written a number of articles on finding cheap Florida condo insurance online.

Maintreaming MEMS - Microfluidic Delivery Systems Are Now A Reality

Wednesday, February 28th, 2007

While “nanotechnology” has been a popular buzz word among investors and researchers, “microtechnology” has graduated from university research labs into commercialized realities. MEMS (Micro-Electro Mechanical System) technology has been around since the late 1970’s, and had a huge surge in popularity in the 1990’s with the telecommunications industry because it could be used to make fiber optic switches at the microscopic scale.

Nowadays, MEMS devices are used commonly for digital projectors, accelerometers, automotive sensors, and medical applications. Based on silicon wafer integrated circuit (IC) etching technology, MEMS devices are actually mechanical actuators fabricated at the microscopic level.

The Industry Sees Benefits

Recently, the pharmaceutical medical device industry has recognized the benefits of MEMS, leading to the development of a whole new industry of miniaturized, microfluidic drug delivery systems. Although many drugs are being used in microfluidic systems, the one that has held the most appeal for consumers and industry alike is insulin for diabetics. With insulin-dependent diabetes on the rise, there is a huge market for implantable, painless, automatic insulin devices that give precise dosages based on automatically sensed needs of the patient. As always, these devices need to be cheap, which means the MEMS fabrication process needs to be able to produce large volumes, something that has been a challenge until recently.

According to the Centers for Disease Control, from 1997 to 2004, the incidence of diabetes among 45- to 79-year-old patients rose 43 percent. Now, about 12 of every 1000 people over 45 will become diabetic. This means about 3.6 million people in the United States in 2004 were diabetic. Looking at hospital discharges in 2005, over 6.4 million people were hospitalized for diabetes, and a conservative cost for these hospitalizations was $22 billion. Obviously, societal costs due to lost wages, lost earning years, and other medical conditions complicated by the presence of diabetes, would increase this figure dramatically.

Diabetic patients often complain of how difficult it is for them to properly regulate their insulin dosage. Not only does it require them to collect a blood sample for analysis, but then they must administer that dose intravenously. In an elderly or obese patient, this is complicated by poor vision, lack of coordination, and fat, all of which make injecting a proper dose more difficult. Hospitals also make mistakes when administering drug doses, some reports putting these mistakes as high as 200,000 serious injuries and 7,000 deaths in the U.S. each year. Microfluidic drug delivery systems address all these problems and have additional advantages as well.

Configuring Microfluidic Systems

Microfluidic drug delivery systems have three main components; a needle array, a pump and valve system, and chemical sensors. The needle array is usually hundreds of microscopic silicon wafer etched needles with orifices for the drug to pass through. Because these needles are so small, they are painless, and yet their vast quantity delivers the drug instantly.

The pumps and valves are also microfabricated, and can be integrated with the needle array and implanted under the skin. The pumps come in two varieties, either passive with some type of electrode or other stimulating means for fluid flow, or active with valves that can control the precise dose being administered at the micro-volume scale.

The third and most important feature of MEMS insulin delivery systems is the chemical sensor which can detect the level of blood glucose in the patient and automatically administer a precise dose of insulin to correct their glucose levels. Thus, the patient and the hospital are removed from the maintenance process. The patient has a discreet, refillable insulin pouch, and all of the glucose control is maintained 24 hours a day with no pain, measuring, or administration required.

Integrated Solutions Hold Promise

Leaders in the market for microfluidic insulin pumps, such as ISSYS, Eksigent, Debiotech, and Biophan, are all focusing on integrated solutions that can be produced in volume. They realize that the key to success will be to provide a low cost, complete system that can be implanted in an out-patient procedure, monitored by sensors within the sensor system, and refilled with insulin by the patient. The market for microfluidic insulin pumps is expected to reach $2 billion by 2010, with substantial continued growth over the following ten years.

Biomedical applications are already the second largest application area for MEMS technologies after automotive; however, to date commercial success has been limited to sensors that measure physical (heart rate) rather than biochemical parameters (glucose). Other than glucose, there are no in vivo sensors in widespread clinical use for monitoring metabolites, such as cancer cells.

Implantable drug infusion pumps were first used with terminally ill cancer patients in the 1980s, but these worked on a predetermined drug release schedule into the blood stream with no sensor feedback from the patient and no targeting of the drug to the cancerous cells. Now, researchers are beginning to use MEMS to improve the delivery of drugs to cancer cells.

Breast Cancer, Blood Cells & Pacemakers

The biochemical signals that guide breast cancer tumor cell migration are poorly understood, but new microfluidic devices designed specifically to track how breast cancer cells move in response to chemical signals are under development. This will allow doctors to decrease the amount of cell-killing drugs administered to the patient and allow the those drugs to target only the cancer cells, rather than any cells they contact. For women with breast cancer, this could mean an end to hair loss, debilitating fatigue, and other detrimental side effects associated with chemotherapy.

Sandia National Labs has created a mechanized microfluidic device that can ingest red blood cells and alter them in a positive fashion. Eventually, they hope to expand their device to work with any cells in the body. The ultimate goal of the Sandia device is to puncture cells and inject them with DNA, proteins, or pharmaceuticals to counter biological or chemical attacks, gene imbalances, and natural bacterial or viral invasions.

Electrical stimulation devices, such as the pacemaker and defibrillator, have been the most successful products of microelectronic implants. But now, pressure and flow sensors are being added to pacemakers to make them rate-responsive. This will enable patients to be more active, as the pacemaker will respond to increased or decreased demands according to the needs of the moment.

In another electrical application, Transneuronix, Inc. has made an implantable gastric stimulator that applies electrical stimulation to the stomach wall. The company is currently conducting clinical trials for the treatment of severe obesity. Rather than a risky, expensive surgical procedure such as gastric bypass, the stomach will continue to digest food, but the stretch and chemical receptors in the wall of the stomach will provide neural feedback to the patient that they are full.

And, Medtronics’ “Activa” system delivers a mild electrical stimulation to block brain signals that cause tremors, such as Parkinson’s disease.

Opportunities Seem Endless

For the medical device industry, this is a wake up call to seek out MEMS and microfluidic solutions to large-scale problems we face in the United States. With the growing epidemics of obesity, diabetes, heart disease, and cancer, there are countless opportunities for large and small companies alike to develop sensor-based diagnostic and therapeutic devices that will help patients live longer, healthier lives with less invasive procedures.